estrogen priming protocol success over 40 combivent

Started doing the patches 10 days before my period was scheduled to start. Good luck & stay positive!! Beta 1117 Just not sure what type of protocol would be best. Estrogen Priming is completely different, so therefore without birth control pill. How many follicles were you usually starting with? Some clinics use EPP more than others. Whats important to stress here is that just because some low dose approaches drive comparable rates of success to conventional approaches, that doesnt mean all low-or-no dose approaches are effective. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. I just had my ER last week: . Changed MD's and now this is the protocol they have in place for me. Have questions about navigating your Inspire support community or need assistance from one of our Inspire Moderators? There is a ton of data out there for 'younger' women 35-42 with fertility issues but I'd like to be able to g, I was taking Estrace and Androderm patch when I went in for my base sonogram and they said I was already ovulating! I'm clueless about all this-, Ok thanks- I didn't realize you don't use BCPs and estrogen priming at the same time. poor responders or women with PCOS). Transfer was canceled. Thanks so much in advance! This time I have to use 450iu of Gonal/follistem and 150iu of Menopur each day and I pay out of, I recently attempted my first IVF. HiI'm new. After 2 years, tons of tests and 5 IVF cycles, it still feels unreal.Estrogen Priming protocol does not have birth control pills. Pre-treatment is known to improve the response of the ovary to the stimulation cycle and also reduces the risk of ovarian cyst formation. Thanks so much! A Group Leader is a What to Expect community member who has been selected by our staff to help maintain a positive, supportive tone within a group. Cool.let me know what he says if you would please. Wow that did make a huge difference for you! Spandorfer said it would not suppress me to much not sure about this, need to speak with him further. I was on BCP for 20 years (have been off for several now) and it took me a long time to normalize after coming off them. I did estrogen priming after my first Ivf cycle ended in mc (nothing to freeze) & my 2nd cycle was canceled bc I wasn't responding well to stims. In the next section well walk you through the mechanics of each protocol. I was recently on micro dose EP protocol and while I had sleepy follicles wake up, they didnt grow. You currently have javascript disabled. Those 2 were my worst cycles. I hope a tweak of the protocol will help or maybe it was just an off cycle for me. SG usually sticks to their protocol for the first round, then if it fails, they'll start customizing. Estrogen priming has worked both times for me. Copyright 2023 I hope you like the protocol. Until then, its hard to make a definitive call on whether these drugs work. Any success stories for low responders of Estrogen Priming cycle? All rights reserved. Terms of Use - Find advice, support and good company (and some stuff just for fun). I dont know much.But my RE will do EEP for my second cycle..I'm just reading alot on the net, http://estrogenprimingprotocol.blogspot.com/. Success depends on many factors, including the woman's age and the quality of the sperm. Please re-enable javascript to access full functionality. Search Beta 2093 We're banking this cycle and testing them with the biopsies from the next. This hormone is injected by the patient and directly instigates the ovaries to grow more follicles. my RE is going back to the drawing board for my final IVF. A gonadotropin-releasing antagonist hormone (GnRH-ant) is used to stop the ovaries from releasing the matured eggs and allows time for additional maturation until eggs are retrieved for fertilization. Group Black's collective includes Essence, The Shade Room and Naturally Curly. I only felt icky on the ganirelix. I am interested in hearing from women who have never tried to get pregnant and therefore do not have any specific infertility issue per se, other than age. Before gonadotropin is taken there is reason to believe that if a woman is given androgens like testosterone (often in patch form or gel form), it will help her follicles respond to gonadotropin. Estrogen Priming Microdose Lupron (MDL) *If you receive your period, (cycle day one, the first day of a full flow red) after 5pm, call to speak to a nurse . He usually gives the BCP before overlapping with lupron as a way to lower FSH and LH. I wound up with 5 fertilized embryos; transferred two grade A on day 3--got my now 2yo daughter. Only 2 drugs during stim and finally got one good pgs tested embryo!!! That could be bogus, but it makes sense, right? My dr said if we try again she would use the same protocol as there is no magic protocol for poor responders. They are generally used for suppression in Long Lupron Protocols. Just devastated with my results today so just want to cry it out and then I will respond to you. This helps to improve the outcome of the IVF cycle in patients who respond poorly to traditional IVF protocols. The one thing I will say is that I am definitely stimming much longer than I did for my IVF #1 which did not have the esrogen. What affect did the epp have on your follicles? Will let you know how things go from here. 3rd IVF age 42 : Short protocal Menopur 375; so far on Day 4 scan 2 focilles again and some very small ones The deadline for sending in seeds was October 15th, but there are still plenty of ways to get involved. This typically happens with conventional insemination where the egg and the sperm are placed in the same culture environment for fertilization DS was born June 22nd, 2007!!!!! Just curious to see if any out there have had any luck getting pregnant at age 43+ and produced a child through IVF. Estrogen Priming Protocol: In some women who respond poorly to the short protocol (e.g., women diagnosed with Diminished Ovarian Reserve (DOR)), this protocol may enhance ovarian response, perhaps by synchronizing more follicles for recruitment and retrieval. I sounds like a good plan since the first protocol didn't work out so great. More than I wanted, I think! I just had a consultation with an RE he recommended a "estrogen priming micro-flare lupron" protocol. Anyhow, do you know how what they wanted the priming to do? For many gardeners, it starts with tomatoes. 1) focus on the quality (not quantity) of eggs. Good luck! Had my ER today - they got 15 eggs. Take a look at the data below published on roughly 1,000 fresh transfers and 1,000 frozen transfers. Estrogen priming through luteal phase and stimulation phase improved ovarian responsiveness and this may lead to an increase in pregnancy rate in poor responders with failed cycle. I did EPP, using a climara patch every other day starting day 8 after ovulation until period came. And finally I triggered with Novarel. This drug works indirectly by prompting the brain to produce more gonadotropin to signal the ovaries to grow follicles -- so it's not directly stimulating the ovary. Though I had 4 or 5 follicles to begin with, only ended . Our usual regimen is similar to those proposed below: hysteroscopy, prolonged estrogen priming, Estring for local effects, baby aspirin, vaginal phosphodiesterease inhibitors, pentoxifylline, acupuncture, etc., with admittedly little data to support any of our treatment strategies. There are 2 - 3 core protocols: the Long Agonist, Antagonist and Flare. Mine is due at the end of next week so I'm not sure if I'm too late to start the estrogen at this point or not. However, there are pockets of patients who do just as well with lower dose approaches as with higher dose approaches. . Typically, a poor responder is someone who meets two of three criteria: they have collected three or fewer eggs on a previous cycle, is over age 40, or who has a diminished ovarian reserve (antral follicle count below 5 or an AMH below below 0.5). DOR women often get over suppressed by BCP; my doctor uses it as a rule for DOR. This is done by administering estrogen, typically via an estrogen patch or an injection, sometimes along with additional Gonadotropin-releasing hormone. After seven long years consumed by infertility I am finally moving forward, wishing my son was with me, but grateful for the two children I have here with me. However, weve yet to see a large, rigorous, prospective, randomized trial on the subject. I will be doing an FET in March/April, I started taking 4mg of estrace on cd 21. My skin looked pretty good for those priming weeks. Buy Organic Seeds Risk Free From Organic Seeds TOP - Credit Card & Western Union Payment Options, Organic Seeds TOP is a seed vendor based in the Ukraine. Similarly, when an investigator named Revelli decided to swap out a few days of gonadotropin for clomid in this poor responder population in Italy (and thereafter resumed gonadotropin at low levels), he saw similar rates of success to more conventional levels of gonadotropin use. However, when it comes to specific IVF populations, its clear that certain strategies and doses are better than others. It helps your lining and encourages your eggs to all grow at the same rate. I also did ganirelix during this time. Most of the encouraging studies have been in poor responders, but because the trials were so small, most never met statistical significance. 2nd IVF/ICSI age 42 : Menopur 425; 2 eggs; 2 fertislised; transfer day 5; BFN I am 38. I am 40 and have a low ovarian reserve. You still may have a BFP, so let's wait to see before we say it didn't work!! Gonal f 225, menopur 75. Learn more about. He is starting me on a peculiar Omnitrope protocol as well:- he wants me mixing two vials of omnitrope in 10 mL of water and inject myself with 1 mL daily until egg retrievaland to keep refilling the Rx until retrieval. E2 level 96.4. DOR does suck, but you can still be successful! Now this is a guesstimated number. Heres an example from the same study. Around 50-60% of couples find success with IUI after 5 cycles, which is about a 10-20% success rate per cycle. AMH 28. Im on this for 21 days starting on cycle day 1. On the other hand, if too much gonadotropin is taken, a woman is at higher risk of hyperstimulation, known as Ovarian Hyperstimulation Syndrome or OHSS. Our first cycles sound pretty similar. When do you start your next cycle? Estrogen priming refers to supplementing women with extra estrogen (estradiol) during the luteal phase - that's the last two weeks - of the prior menstrual cycle before beginning ovarian hyper-stimulation for IVF. Looking for info/success stories with Estrogen priming protocol with DOR. Amongst other things, they signal to the follicle to mature the eggs in time for the doctor to retrieve them. Best of luck choosing. Estrogen is administered during the luteal phase of the previous menstrual cycle to "prime" the FSH receptors which enhances the response to FSH. The company offers Elephant Gigantes seeds, as well as free seeds that come with recommended shelf life information included. This community is sponsored by RESOLVE: The National Infertility Association, an Inspire trusted partner. Estrogen Priming Protocol: For some women, especially for those who have diminished ovarian reserve, it becomes necessary to help the response to the Antagonist protocol. IVF#3 September 2009 - cancelled - poor response 45 and over - who are trying to get pregnant. 14 retrieved, 9 mature, 5 fertilized normally, 2 grew to the 2-cell stage then arrested, 3 did not grow beyond one cell. IVF#5 July 2010 - will be using estrogen priming Several functions may not work. In the case of the fresh transfers, you can clearly see a similar effect to what investigators found above: success rates drop with more drug. Experience with Estrogen Priming Protocol? Once you surge (and presumably ovulate) you count 10 days from the surge. Estrogen priming is a protocol used during in vitro fertilization (IVF) to facilitate a more gradual and coordinated growth of follicles in the ovary in women with diminished ovarian reserve (DOR). We are going to bump up my gonal f too. I never hoped so I never even asked that question. I will probably stim for 12-13 days! The answer lies in the drug the protocol uses to trigger the eggs to mature so that they can be retrieved. This is the most commonly used protocol whose primary features are a shorter duration of injections and a far lower rate of OHSS, thanks to the ability to use Lupron as a trigger. Cost: $1,000. There are two types of gonadotropin FSH and LH and most data shows you need both during an IVF cycle. Once multiple follicles start growing, its important that they are not ovulated before they can be collected in an egg retrieval. We're also doing PGS. There seems to be two schools of thought: RE put me on Estrogen priming protocol, and I am on Lupron and Cetrotide as well.On Friday, (cycle day 6) the newer nurse thought she saw 11 follicles.. ranging from 5mm to 9mm.. now, Cycle day 9, the other nurse, who has been there forever, saw only 5 and she had a hard time locating my other ovary. Froze 3. Trying concieve since 40 First, the analysis was retrospective and not prospective. IVF Compared To Other Fertility Treatments, The Steps and Decisions In The IVF Process, Pregnancy Testing, Early Pregnancy and Delivery, The Impact of Donor Eggs, Donor Sperm or A Gestational Surrogate, The Impact of A Patients Condition or Diagnosis, Fertilization With Conventional Insemination vs. ICSI, Which Patients Benefit From Which Approach, Growing Embryos To Cleavage or Blastocyst Stage, Exceptions Where Cleavage Stage Makes Sense, PGT-A and PGS Genetic Screening of Embryos, Benefits of PGT-A (or PGS) Genetic Testing, The Negatives of PGT-A (or PGS) Genetic Screening. Im over 40 and did estrogen priming for a bunch of cycles and a Lupron stop. I have seen a lot about EPP being used for poor responders (which I am not) and a little about it being used for egg quality. By: Kelly Park Group Leaders arent expected to spend any additional time in the community, and are not held to a set schedule. BFP October 22!!!! My first IVF cycle I was on the antagonist with stims started on Day 3.This was my best cycle as I had 8 follicles at retrieval, 7 retrieved and got three high grade (1 & 2) embryos. I started taking 4mg of estrace on cd 21. Estrogen priming is pretty standard for over 40. They are concerned about egg quality. Baby boy born May 2, 2013, Full details are now in my profile "About Me" page. Clomid is cheap, easy to take (oral), drives less risk of OHSS, but is less effective. Thank you for subscribing to our newsletter! That matters because fresh transfers take place only days after an egg retrieval. As you can see below, amongst women with PCOS, the Antagonist protocol drives comparable success rates but with far lower risk of hyperstimulation. Get Ready for a New Season of Gardening -Choose from Tomatoes, Peaches, Corn, Zinnias & More! I went to a UK FSH friendly (thank you joy for the recommendation) clinic for a consultation. This is the oldest IVF protocol and is especially effective in preventing premature ovulation during the cycle. Doing mild IVF - and wondering how that is going to work as the test today was that i only had one follicle visible - Any idea what to expect? (51.2% vs 25%; p = 0.047) were noted. FET April 2009 - cancelled, embryos did not survive thaw I have been doing some research and reading and I was reading that for older patients, a different protocol where less meds are used is usually recommend. 2 Girls!! We are OOP as well. Hey Michelle, I haven't forgotten about you. Ganirelix is contraindicated in pregnancy. I think you both are at Cornell (were) with this estrogen priming protocol will you try again with them, and request not to do estrogen priming? Thanks! As a result, its hard to correct for confounders like the fact that harder cases may (or in our minds, probably) had been given more drug and so the underlying condition, rather than the dose taken, contributed to the lower rates of success. I mean, you could try to get pregnant naturally, since as far as I know taking estrogen priming (particularly Estrace medication) should not harm your fetus if you were to become pregnant. Very helpful! And I think EPP is the standard at CCRM as well for DOR ladies. However, the study has two major shortcomings and for that reason most experts arent ready to concede that rates of gonadotropin over 300 IUs per day is harmful. They monitor the follicle size and u do the trigger still so the know when to retrieve. IVF#4 November 2009 - one embryo survived to day 3 transfer - BFN Estrogen priming is usually matched with an antagonist to prevent ovulation. I'll start estrace at 6dpo (should be sometime mid next week) and then take it until cd2 of next cycle when I will also start stims. As we discussed there are drugs that stimulate follicles to grow, suppress the follicles ability to release their eggs, and then help catalyze the follicles to mature their eggs so they can be retrieved. I think you should ask your doctor though to make sure.Again, here is what happened to my protocolCycle day 1 - PeriodCycle day 24 (7 days post ovulation) - Start Estrace Cycle day 1 - Period Cycle day 2 - Last Estrace pill Cycle day 3 Blood work & ultrasound; antral follicle count. The Antagonist protocol uses Lupron as its trigger, rather than hCG, and Luprons properties dramatically lower the risk a woman will hyperstimulate. Some people prefer the term Diminished Ovarian Reserve or Low Egg Reserve for patients who meet this criteria, as the ovarian response to medications for this group is not always necessarily poor, but rather is simply expected to be lower at their given baseline. I need to know if anyone has had a similar experience, but later got pregnant and where did you go. Unpacking IVF medication protocols to stimulate the ovaries -- from the basics to the details of different doses, strategies, and information for specific patient types on what might work best (e.g. Typically, you also add other stims once you start your cycle, too (Menopur, GonalF), so those could be in high doses. I am anxious to see if my dr recommends it. My story: I'm 34, DH 32. TBD how many fertilize, etc. Has anyone who makes a good amount of eggs used this protocol?

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